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1

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Ernestina Schipani, Christa Maes, Geert Carmeliet, Gregg L Semenza

Journal:

Journal of Bone and Mineral Research

Year:

2009

Language:

english

File:

PDF, 764 KB

english, 2009

2

Structure-function studies with recombinant PTH/PTHrP receptors

Harald Jüppner, Ernestina Schipani, Gino V. Segre, Abdul-Badi Abou-Samra, Thomas J. Gardella

Journal:

Journal of Bone and Mineral Metabolism

Year:

1994

Language:

english

File:

PDF, 407 KB

english, 1994

3

Role of HIF-1α in skeletal development

Chao Wan, Jin Shao, Shawn R. Gilbert, Ryan C. Riddle, Fanxin Long, Randall S. Johnson, Ernestina Schipani, Thomas L. Clemens

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 97 KB

english, 2010

4

Hypoxia and HIF-1α in chondrogenesis

Ernestina Schipani

Journal:

Seminars in Cell & Developmental Biology

Year:

2005

Language:

english

File:

PDF, 297 KB

english, 2005

5

Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development

Mangiavini, Laura, Merceron, Christophe, Araldi, Elisa, Khatri, Richa, Gerard-O’Riley, Rita, LeShan Wilson, Tremika, Rankin, Erinn B., Giaccia, Amato J., Schipani, Ernestina

Journal:

Developmental Biology

Year:

2014

Language:

english

File:

PDF, 18.22 MB

english, 2014

6

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

Merceron, Christophe, Mangiavini, Laura, Robling, Alexander, Wilson, Tremika LeShan, Giaccia, Amato J., Shapiro, Irving M., Schipani, Ernestina, Risbud, Makarand V., Kletsas, Dimitris

Journal:

Year:

2014

Language:

english

File:

PDF, 17.76 MB

english, 2014

7

PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development

Ernestina Schipani, Sylvain Provot

Journal:

Birth Defects Research Part C: Embryo Today: Reviews

Year:

2003

Language:

english

File:

PDF, 1.14 MB

english, 2003

8

Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development

Francesca Gori, Ernestina Schipani, Marie B. Demay

Journal:

Journal of Cellular Biochemistry

Year:

2001

Language:

english

File:

PDF, 402 KB

english, 2001

9

Bone marrow mesenchymal stem cells

Masanobu Ohishi, Ernestina Schipani

Journal:

Journal of Cellular Biochemistry

Year:

2010

Language:

english

File:

PDF, 111 KB

english, 2010

10

Per-1 is a specific clock gene regulated by parathyroid hormone (PTH) signaling in osteoblasts and is functional for the transcriptional events induced by PTH

Ryo Hanyu, Tadayoshi Hayata, Masashi Nagao, Yoshitomo Saita, Hiroaki Hemmi, Takuya Notomi, Tetsuya Nakamoto, Ernestina Schipani, Henry Knonenbery, Kazuo Kaneko, Hisashi Kurosawa, Yoichi Ezura, Masaki

Journal:

Journal of Cellular Biochemistry

Year:

2011

Language:

english

File:

PDF, 218 KB

english, 2011

11

Constitutively active PTH/PTHrP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation

Noriaki Ono, Kazuhisa Nakashima, Ernestina Schipani, Tadayoshi Hayata, Yoichi Ezura, Kunimichi Soma, Henry M. Kronenberg, Masaki Noda

Journal:

Journal of Cellular Physiology

Year:

2012

Language:

english

File:

PDF, 785 KB

english, 2012

12

Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling

Ryan C. Riddle, Richa Khatri, Ernestina Schipani, Thomas L. Clemens

Journal:

Journal of Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 181 KB

english, 2009

13

Extracellular matrix genes as hypoxia-inducible targets

Johanna Myllyharju, Ernestina Schipani

Journal:

Cell and Tissue Research

Year:

2010

Language:

english

File:

PDF, 535 KB

english, 2010

14

A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

Erinn B. Rankin, Amato J. Giaccia, Ernestina Schipani

Journal:

Current Osteoporosis Reports

Year:

2011

Language:

english

File:

PDF, 156 KB

english, 2011

15

Posttranslational modifications of collagens as targets of hypoxia and Hif-1α in endochondral bone development

Ernestina Schipani

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 93 KB

english, 2010

16

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

Araldi, Elisa, Khatri, Richa, Giaccia, Amato J, Simon, M Celeste, Schipani, Ernestina

Journal:

Nature Medicine

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

17

Hypoxia and HIF-1α in Chondrogenesis

ERNESTINA SCHIPANI

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

18

Fetal Growth Plate : A Developmental Model of Cellular Adaptation to Hypoxia

SYLVAIN PROVOT, ERNESTINA SCHIPANI

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 103 KB

english, 2007

19

Hypoxia-driven pathways in bone development, regeneration and disease

Maes, Christa, Carmeliet, Geert, Schipani, Ernestina

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

20

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival

Christa Maes, Elisa Araldi, Katharina Haigh, Richa Khatri, Riet Van Looveren, Amato J Giaccia, Jody J Haigh, Geert Carmeliet, Ernestina Schipani

Journal:

Journal of Bone and Mineral Research

Year:

2012

Language:

english

File:

PDF, 4.25 MB

english, 2012

21

Molecular mechanisms of endochondral bone development

Sylvain Provot, Ernestina Schipani

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 576 KB

english, 2005

22

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

Yukiko Maeda, Ernestina Schipani, Michael J. Densmore, Beate Lanske

Journal:

Year:

2010

Language:

english

File:

PDF, 2.06 MB

english, 2010

23

Hypoxia, HIFs and bone development

Elisa Araldi, Ernestina Schipani

Journal:

Year:

2010

Language:

english

File:

PDF, 602 KB

english, 2010

24

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

Erinn B. Rankin, Colleen Wu, Richa Khatri, Tremika L.S. Wilson, Rebecca Andersen, Elisa Araldi, Andrew L. Rankin, Jenny Yuan, Calvin J. Kuo, Ernestina Schipani, Amato J. Giaccia

Journal:

Year:

2012

Language:

english

File:

PDF, 1.51 MB

english, 2012

25

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation

Jun Guo, Minlin Liu, Dehong Yang, Mary L. Bouxsein, Hiroaki Saito, R.J. Sells Galvin, Stuart A. Kuhstoss, Clare C. Thomas, Ernestina Schipani, Roland Baron, F. Richard Bringhurst, Henry M. Kronenberg

Journal:

Cell Metabolism

Year:

2010

Language:

english

File:

PDF, 2.21 MB

english, 2010

26

Haplotype frequencies and linkage disequilibrium analysis of four frequent polymorphisms at the PTH/PTH-related peptide receptor gene locus

Leopold F Fröhlich, Robert C Gensure, Ernestina Schipani, Harald Jüppner, Murat Bastepe

Journal:

Molecular and Cellular Probes

Year:

2004

Language:

english

File:

PDF, 93 KB

english, 2004

27

Nf2/Merlin Regulates Hematopoietic Stem Cell Behavior by Altering Microenvironmental Architecture

Jonas Larsson, Masanobu Ohishi, Brian Garrison, Marie Aspling, Viktor Janzen, Gregor B. Adams, Marcello Curto, Andrea I. McClatchey, Ernestina Schipani, David T. Scadden

Journal:

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

28

Osteoprotegerin Abrogated Cortical Porosity and Bone Marrow Fibrosis in a Mouse Model of Constitutive Activation of the PTH/PTHrP Receptor

Masanobu Ohishi, Riccardo Chiusaroli, Michael Ominsky, Frank Asuncion, Clare Thomas, Richa Khatri, Paul Kostenuik, Ernestina Schipani

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 2.28 MB

english, 2009

29

Hypoxic Regulation of Nucleus Pulposus Cell Survival: From Niche to Notch

Makarand V. Risbud, Ernestina Schipani, Irving M. Shapiro

Journal:

The American Journal of Pathology

Year:

2010

Language:

english

File:

PDF, 436 KB

english, 2010

30

Properties of amino-terminal parathyroid hormone-related peptides modified at positions 11–13

Jüppner, Harald, Abou-Samra, Abdul-Badi, Uneno, Susumu, Schipani, Ernestina, Keutmann, Henry T., Potts, John T., Segre, Gino V.

Journal:

Year:

1990

Language:

english

File:

PDF, 396 KB

english, 1990

31

The Interplay of Osteogenesis and Hematopoiesis: Expression of a Constitutively Active PTH/PTHrP Receptor in Osteogenic Cells Perturbs the Establishment of Hematopoiesis in Bone and of Skeletal Stem Cells in the Bone Marrow

Sergei A. Kuznetsov, Mara Riminucci, Navid Ziran, Takeo W. Tsutsui, Alessandro Corsi, Laura Calvi, Henry M. Kronenberg, Ernestina Schipani, Pamela Gehron Robey and Paolo Bianco

Journal:

The Journal of Cell Biology

Year:

2004

Language:

english

File:

PDF, 3.34 MB

english, 2004

32

The PTH/PTHrP receptor in Jansen’s metaphyseal chondrodysplasia

Calvi, L. M., Schipani, Ernestina

Journal:

Journal of Endocrinological Investigation

Year:

2000

Language:

english

File:

PDF, 360 KB

english, 2000

33

Announcements

Calvi, L. M., Schipani, Ernestina

Journal:

Journal of Endocrinological Investigation

Year:

2000

Language:

english

File:

PDF, 39 KB

english, 2000

34

Hif-1 a Regulates Differentiation of Limb Bud Mesenchyme and Joint Development

Sylvain Provot, Dawn Zinyk, Yasemin Gunes, Richa Kathri, Quynh Le, Henry M. Kronenberg, Randall S. Johnson, Michael T. Longaker, Amato J. Giaccia and Ernestina Schipani

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 4.60 MB

english, 2007

35

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

Simic, Petra, Zainabadi, Kayvan, Bell, Eric, Sykes, David B., Saez, Borja, Lotinun, Sutada, Baron, Roland, Scadden, David, Schipani, Ernestina, Guarente, Leonard

Journal:

EMBO Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 240 KB

english, 2013

36

ATF4 and HIF-1α in bone: An intriguing relationship

Schipani, Ernestina, Mangiavini, Laura, Merceron, Christophe

Journal:

Journal of Bone and Mineral Research

Year:

2013

Language:

english

File:

PDF, 80 KB

english, 2013

37

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

Simic, Petra, Zainabadi, Kayvan, Bell, Eric, Sykes, David B., Saez, Borja, Lotinun, Sutada, Baron, Roland, Scadden, David, Schipani, Ernestina, Guarente, Leonard

Journal:

EMBO Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 912 KB

english, 2013

38

Otoconin-22 and Calcitonin: A Novel Modality of Regulating Calcium Storages in Lower Vertebrates?

Schipani, Ernestina

Journal:

Year:

2003

Language:

english

File:

PDF, 39 KB

english, 2003

39

HIF targets in bone remodeling and metastatic disease

Johnson, Rachelle W., Schipani, Ernestina, Giaccia, Amato J.

Journal:

Pharmacology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 732 KB

english, 2015

40

Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis

Schipani, Ernestina, Wu, Collen, Rankin, Erinn B., Giaccia, Amato J.

Journal:

Frontiers in Endocrinology

Year:

2013

Language:

english

File:

PDF, 851 KB

english, 2013

41

Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing

Marsell, Richard, Jonsson, Kenneth B, Cho, Tae-Joon, Einhorn, Thomas A, Ohlsson, Claes, Schipani, Ernestina

Journal:

Acta Orthopaedica

Year:

2007

Language:

english

File:

PDF, 5.80 MB

english, 2007

42

Chrondocytes: a few grains of softness in a hard bone world (ASBMR 2012)

Merceron, Christophe, Schipani, Ernestina

Journal:

Year:

2013

Language:

english

File:

PDF, 117 KB

english, 2013

43

The Importance of Autosomal Genes in Kallmann Syndrome: Genotype-Phenotype Correlations and Neuroendocrine Characteristics 1

Oliveira, Luciana M. B., Seminara, Stephanie B., Beranova, Milena, Hayes, Frances J., Valkenburgh, Sarah B., Schipani, Ernestina, Costa, Elaine Maria F., Latronico, Ana Claudia, Crowley, William F., V

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 204 KB

english, 2001

44

Intervertebral disc: a rising star in the skeleton galaxy (ASBMR 2012)

Merceron, Christophe, Schipani, Ernestina

Journal:

Year:

2013

Language:

english

File:

PDF, 101 KB

english, 2013

45

HIF-1α and growth plate development: what we really know

Schipani, Ernestina, Mangiavini, Laura, Merceron, Christophe

Journal:

BoneKEy Reports

Year:

2015

Language:

english

File:

PDF, 742 KB

english, 2015

46

Bsml polymorphism at the parathyroid hormone receptor locus (PTHR) in three populations

Hustmye, Frank G., Schipani, Ernestina, Peacock, Munro

Journal:

Human Molecular Genetics

Year:

1993

Language:

english

File:

PDF, 85 KB

english, 1993

47

Phospholipase C Signaling via the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Is Essential for Normal Bone Responses to PTH

Guo, Jun, Liu, Minlin, Yang, Dehong, Bouxsein, Mary L., Thomas, Clare C., Schipani, Ernestina, Bringhurst, F. Richard, Kronenberg, Henry M.

Journal:

Year:

2010

Language:

english

File:

PDF, 860 KB

english, 2010

48

The Roles of Parathyroid Hormone and Calcitonin in Bone Remodeling: Prospects for Novel Therapeutics

Carter, Percy, Schipani, Ernestina

Journal:

Endocrine Metabolic & Immune Disorders - Drug Targets

Year:

2006

Language:

english

File:

PDF, 407 KB

english, 2006

49

Selective and Nonselective Inverse Agonists for Constitutively Active Type-1 Parathyroid Hormone Receptors: Evidence for Altered Receptor Conformations 1

Carter, Percy H., Petroni, Brian D., Gensure, Robert C., Schipani, Ernestina, Potts Jr., John T., Gardella, Thomas J.

Journal:

Year:

2001

Language:

english

File:

PDF, 341 KB

english, 2001

50

Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis

Larsson, Tobias, Marsell, Richard, Schipani, Ernestina, Ohlsson, Claes, Ljunggren, Östen, Tenenhouse, Harriet S., Jüppner, Harald, Jonsson, Kenneth B.

Journal:

Year:

2004

Language:

english

File:

PDF, 426 KB

english, 2004